For more information about some of these interactions, see the Drug interactions explained section below. Certain health conditions or other factors could raise your risk of harm if you take Contrave. They can recommend a treatment other than Contrave for you. Before you start treatment with Contrave, tell your doctor and pharmacist if you use cannabis. Talking with others can give you the motivation you need to continue. Its used alongside exercise and a balanced diet to help certain adults lose weight. If you do not lose at least 5% of your body weight within 12 weeks of starting treatment, you should stop Contrave, as it is unlikely that it will work for you. Naltrexone is an opioid antagonist that blocks the effects of opioid-like drugs i.e heroin. Overall, patients can expect to lose two to four times more weight with Contrave than with diet and exercise alone. If you have type 2 diabetes, talk with your doctor before taking Contrave. How does Ozempic work? It is very safe as well and has a long track record. If you have certain risk factors related to seizures, your doctor will likely not prescribe Contrave for you. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Does my health history affect whether I should take Contrave? Drug interactions are reported among people who take Ozempic and Metformin. WebMD does not provide medical advice, diagnosis or treatment. This condition is a medical emergency. The drug is used to treat pain and swelling. rybelsus and jardiance together. Add your drug list to My Med List to view medical information in a simple, easy-to-read, personalized format. Many weight loss clinics use this combo. How can [], Article Contents What is metformin? Please Check Your Email for Further Instruction. The Get Contrave Now service gives a Contrave price of $99 per month (around $3 per day). Its important to note that you should avoid taking Contrave with high fat foods. I mean, Thats how the popular hair loss drug minoxidil, also known as Rogaine, was discovered. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Generally, a single dose is not a problem. Please Check Your Email for Further But it can be taken with long-acting insulin. Find out about possible interactions with alcohol, other drugs, supplements, foods, and more. Bipolar disorder. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox, BUPROPION COMBINATIONS/STRONG CYP2B6 INDUCERS, BUPROPION/ARIPIPRAZOLE LAUROXIL SUBMICRONIZED, AGENTS THAT AFFECT CATECHOLAMINES/IOBENGUANE I 123, AGENTS THAT AFFECT CATECHOLAMINES/IOBENGUANE I 131, STRONG & MODERATE CYP2D6 INHIBITORS/ELIGLUSTAT, DOPAMINE TRANSPORTER BINDERS/IOFLUPANE I 123, SELECTED STRONG CYP2D6 INHIBITORS/TAMOXIFEN, STRONG 2D6 INHIBITORS/ATOMOXETINE; VORTIOXETINE, SELECTED SENSITIVE CYP2B6 SUBSTRATES/MIDOSTAURIN, SELECTED SENSITIVE CYP2B6 SUBSTRATES/LEMBOREXANT, BUPROPION COMBINATIONS/MODERATE CYP2B6 INDUCERS, STRONG CYP1A2 OR CYP2D6 INHIBITORS/FENFLURAMINE, STRONG CYP2D6 OR CYP3A4 INHIBITORS/OLICERIDINE, SELECTED STRONG CYP2D6 INHIBITORS/FLECAINIDE, SELECTED MODERATE TO STRONG CYP2D6 INHIBITORS/TRAMADOL, STRONG CYP2D6 INHIBITORS/DEUTETRABENAZINE;TETRABENAZINE, Treating Opioid Use Disorder With Medications, Constipated? Side effects are more prevalent among patients struggling with a heart condition. Bupropion (one of the active ingredients in Contrave) may interact with certain lab tests. Your doctor will advise you to limit or avoid drinking alcohol if youre prescribed Contrave. If youre unsure about Contrave, consider trying bupropion first if you have the chance to do so, since it might tell you if Contrave would be effective for you in the first place, and would be much easier and cheaper to obtain. Or they may prescribe a drug other than Contrave for you. However, it will put you at risk for accidental overdose. If you take an MAOI or have taken one in the past 14 days, your doctor likely wont prescribe Contrave for you. Gymnema is used to treat conditions like obesity and diabetes. Some combinations may be considered in specific circumstances where benefits outweigh the risks and a doctor deems it safe along with careful medical monitoring. (6). If you take opioids, your doctor likely wont prescribe Contrave for you. But it sure had an interesting side effect of hair growth. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Moderately clinically significant. Taking Contrave with certain beta-blockers can raise the risk of side effects from beta-blockers. If youre breastfeeding or planning to breastfeed, talk with your doctor about your options. Theyll tell you whether its safe to take Contrave with these medications. However, the safety of Contrave in combination with other medications has not been established and so care must be taken if you take other drugs, including herbal remedies. Causes of pancreatitis Is pancreatitis connected to diabetes? When you start Contrave, it is usually prescribed in the following way: Learn more about popular brands, dosage, side effects, results, and weight loss alternatives. Before starting Contrave treatment, tell your doctor if you have closed-angle glaucoma. Opioids are a group of drugs used to treat severe pain. I wish you the best, as losing 60 lbs is difficult, but the good news is that it IS possible! They may also not prescribe Contrave if youve suddenly stopped taking certain medications. OPIOID ANTAGONISTS/OPIOID ANALGESICS BUPROPION;. These conditions can increase your risk of seizures from Contrave. Before starting Contrave treatment, let your doctor know that youre taking amantadine. Certain eating disorders. 1. There are currently no reports of Contrave interacting with vaccines. There are currently no reports of Contrave interacting with herbs. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Breastfeeding. In three clinical trials, people who took Contrave up to 56 weeks lost only five to nine pounds more on average than those who took a placebo. Bupropion is one of the active ingredients in Contrave. The symptoms of lactic acidosis usually set in quickly and include abdominal discomfort, fast, shallow breathing, muscle pain and cramping, and unusual fatigue. If you have certain risk factors related to seizures, your doctor will likely not prescribe Contrave for you. rybelsus and jardiance together. Medications to Avoid While Taking Metformin. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. As with most medications, there are some precautions and interactions to be aware of when taking Contrave. This is because taking the drug could cause another allergic reaction. This is because Contrave may cause seizures as the dose increases. The pills are pale blue and circular. But this doesnt mean that interactions with herbs wont be recognized in the future. Related complications could include high blood pressure, high cholesterol, or type 2 diabetes. Pregnant and breastfeeding women should not take Contrave. Learn about the benefits and advantages of Phen Caps! Contrave.com (How Contrave Works).4. It has been estimated to cause up to 16% body weight loss from the baseline. So, if you prefer oral tablets and can conveniently incorporate them into your lifestyle, Metformin is a better choice. Suddenly stop drinking alcohol or taking certain medications. Email this report to a friend, doctor, or patient. Another combination drug called phentermine/topiramate (Qsymia) is approved for weight loss in adults and in children ages 12 years and older with obesity. It is often used in diabetes. You should avoid or limit the use of alcohol while being treated with these medications. Misbin, Robert (2004) The Phantom of Lactic Acidosis due to Metformin in Patients With Diabetes. If you have severe renal impairment or kidney disease, you might also be at greater risk of developing lactic acidosis because your kidneys cant clear the lactic acid from your system. Check out my article for a more detailed breakdown between the two, but the difference between cravings and hunger is kind of like the difference between wanting to eat, and needing to eat. Contrave works on the food centers of the brain to reduce hunger, whereas Saxenda stimulates insulin production to suppress the appetite. (2). If you take them together or do not wait 2 weeks, you may have confusion, agitation, restlessness, stomach or bowel symptoms, a sudden high body temperature, an extremely high blood pressure, or severe seizures. Even if Contrave is safe for you to use, A lot of people starting Contrave are not willing to continue it for long due to the heavy side effects they experience. If you need help understanding this information, your doctor or pharmacist can help. Wegovy Interactions There are 245 drugs known to interact with Wegovy (semaglutide), along with 6 disease interactions, and 2 alcohol/food interactions. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. While Contrave is expected to be more effective than bupropion for weight loss, many of my patients report that bupropion works quite effectively as an alternative to Contrave, especially in helping with emotional and stress eating. 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This could increase the amount of beta-blocker in your body, which may raise your risk of side effects from the beta-blocker. If you have had an allergic reaction to Contrave or any of its ingredients, your doctor likely wont prescribe Contrave. Note that the information below does not include all other possible interactions with Contrave. We avoid using tertiary references. These are known as contraindications. You should not take CONTRAVE again if you have a seizure. Contrave is a combination drug of both Bupropion and Naltrexone. Highlights Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. BrianYeungND and Dr. Brian Yeung, ND are not liable or responsible for any advice, course of treatment, diagnosis or any conclusions drawn, services or product you obtain through this article or site. Taking certain steps can help you avoid interactions with Contrave. Those who took naltrexone and bupropion lost more weight than those taking a placebo pill. Its usually recommended to split the dose among meals, typically three times per day. selective serotonin reuptake inhibitors (SSRIs). You may give both injections in the same body area (for example, your stomach area), but you should not give the injections right next to each other. Or they may prescribe a different treatment for you instead. On average, patients lowered their hemoglobin A1c levels by over 2% through working with Diana. Product: A weight loss medication. Furthermore, those taking a dose of naltrexone equivalent to the full dose in Contrave were more successful than those taking a half dose. You can ask them about other treatments that may be better choices for you. This article explains the factors that affect how long, Starting a weight loss journey alone can be difficult. Highly clinically significant. I do notice that it sometimes takes a few weeks to actually take effect, so, unlike some of the other weight loss tools that start working right away, you might have to take it for a while before anything happens. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Contrave should not be taken if you already take bupropion (such as Zyban or Wellbutrin) for depression, are withdrawing from drugs or alcohol, or have been prescribed opioid medications. Wadden TA et al. Your doctor can recommend other treatment options for you. 2005 - 2023 WebMD LLC. Your doctor likely wont prescribe Contrave for you if youve recently been drinking alcohol excessively or youve suddenly stopped excessive drinking. Excess insulin is a common trait among PCOS sufferers, which can lead to excess testosterone and disruption of ovulation. These factors include if you take another drug that increases your risk of seizures or if you have a seizure disorder or a condition that may cause seizures. to receive emails from bensnaturalhealth and I Your doctor likely wont prescribe Contrave for you if youve recently been drinking alcohol excessively or youve suddenly stopped excessive drinking. As a result, your risk of side effects from SSRIs may be higher. It does not create a doctor-patient relationship between Dr. Yeung and you. Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees. You can ask them about other treatments that may be better options for you. Automatically receive FDA alerts, drug interaction warnings, plus data on food, allergy & condition interactions. Contrave has active ingredients of bupropion hydrochloride; naltrexone hydrochloride. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527439/, 15 foods to naturally lower blood sugar levels. Things to discuss with them include: Its also important to read Contraves label and other paperwork that may come with the drug. 2015; 91 (8): 554-556.9. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. Kidney or liver damage. Contrave is used to help certain adults lose weight. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. A glaucoma attack may cause sudden blurry vision and eye pain. This medicine is used together with diet and exercise. Lactic acidosis is a serious condition where your body creates more lactic acid than your body can clear. Drug interactions are reported among people who take Contrave and Valium together. Before you start taking Contrave, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. What should I avoid when taking Contrave? Also, if youre actually hungry, Contrave may not do much to reduce that hunger. One of the benefits of metformin is that it doesn't cause low blood sugar. Dr. Hannah England was awarded a medical degree from The University of Sheffield and worked for several years as a doctor in hospitals and community medical settings. Fortunately, there arent many serious metformin drug interactions. There is also an extended-release version of metformin that is designed to be taken once daily. When taken together with metformin, your kidneys might not be able to clear the metformin, which can result in lactic acidosis. Metformin dosages range from 500 milligrams to a maximum of 2,550 milligrams per day. They may prescribe a lower dosage of Contrave than usual. Closed-angle glaucoma. Insulin is a hormone that helps lower blood glucose levels. For reference, if you weigh 200 pounds, a 9.3% reduction is equivalent to losing 18.6 pounds. Find out everything you need to know about weight loss drugs in our prescription weight loss pill guide. If you take opioids. Long story short, I developed a Massive Pulmonary Embolism in my lungs due to the contraceptives. If you have bipolar disorder, talk with your doctor about your condition before starting Contrave. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. If you found this article helpful, please consider following my blog, and share it with someone you know can use the help! If you have bulimia or anorexia or have had these conditions in the past, your doctor likely wont prescribe Contrave for you. Contrave interacts with some medications. So, taking it with alcohol produces a moderate to high drug . Thanks for your comment. Phentermine.com is a property of: Careworld LLC. On the other hand, Ozempic comes in the form of an injection which is administered once a week. Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial. If you have high blood pressure that isnt well managed, your doctor likely wont prescribe Contrave for you. Contrave pills contain two medications. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Common interactions include vertigo among females and dizziness among males. Ozempic vs. metformin: how do they compare? As part of a series of articles on weight loss options, will look in more detail at the ingredients, safety, and success rates of Contrave to help you decide if this medication might be right for you. Among all the weight loss drugs, Wegovy is considered superior. Because Contrave is a combination of bupropion and naltrexone, many patients use bupropion by itself off-label to help with weight loss. You can use the study as a second opinion to make health care decisions. Foods you should avoid while taking [], FYRTORR LTD. (Reg. Lactic acidosis is more likely to occur if you have kidney or liver disease, acute or unstable congestive heart failure, or dehydration. However, some people who do drink alcohol while on Contrave, report that it makes them feel sick, or that the alcohol doesnt seem to have the same effect. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. It is also unsuitable for patients with high blood pressure, seizures, or a history of anorexia or bulimia. Comment * document.getElementById("comment").setAttribute( "id", "a3cde379f03b9d12046b7b320f701247" );document.getElementById("fdaf3f488c").setAttribute( "id", "comment" ); Your email address will not be published. Metformin, the best first choice for diabetics, increases Insulin sensitivity, thereby lowering insulin, which makes it hard to put fatty acids into a fat cell. Before taking Contrave, tell your doctor if you take an MAOI. These medications are not usually taken together. Bupropion may also make your body more sensitive to the effects of alcohol. I have pre-diabetes which I suspect I have had a long time despite normal bloodwork (I had gestational diabetes). Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. 2010; 376 (9741): 595-605.5. Before taking Contrave, tell your doctor about any SSRIs you take. 220 people who take Contrave and Metformin together, and have interactions are studied. * Approximation only. If you are taking an opioid for a short time, your doctor will halt Contrave for that period. If you already take levodopa, an MAOI antidepressant, or amantadine, you should not take this weight loss medication. (1) Contrave was approved for use by the US Food and Drug Administration (FDA) in 2014. (4). Get the best fitness, food, and weight loss tips to succeed on your journey! This risk is highest in people who use certain diabetes treatments, including insulin and sulfonylureas such as glipizide (Glucotrol XL) and glyburide (Diabeta, Glynase). (Naltrexone is one of the active ingredients in bupropion.). Learn more about certain drug interactions that can occur with Contrave. Your doctor can recommend what to do if this happens. Sharing this information with them may help prevent possible interactions. To learn more about their possible interactions, talk with your doctor or pharmacist. Moderate buPROPion food Applies to: Contrave (bupropion / naltrexone) Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. Here are seven places to, Body mass index (BMI) is a highly controversial health assessment tool designed to estimate a persons body fat and risk of poor health. If you still have questions about Contrave and its possible interactions, talk with your doctor. American Family Physician. generic drugs) are not considered. Questions you may want to ask your doctor include: To learn more about Contrave, see these articles: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. It can even become debilitating to the point of causing some people to nearly pass out. The behavior modification included an energy-reduced diet and group counseling sessions. 2023 eHealthMe.com. You can learn more about how we ensure our content is accurate and current by reading our. Greenway FL, Dunayevich E, Tollefson G, et al. A false-positive means the test shows a positive result for a drug that is not actually present. This article provides a helpful guide for healthy eating. Available for Android and iOS devices. To view an interaction report containing 4 (or more) medications, please sign in or create an account. His use of doctor or Dr. in relation to himself solely refers to that degree. I'm new here. Interactions between antidiabetic drugs and herbs: an overview of mechanisms of action and clinical implications. I'm about to pick up my first prescription of Contrave. T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito. Metformin Methadone Methamphetamine Methantheline Methdilazine Methenolone Methicillin . Having a few drinks by itself while on Contrave, does not appear to increase seizure risks, based on the available evidence. Or unstable congestive heart failure, or amantadine, you should not take Contrave with certain can. Does my health history affect whether I should take Contrave to help certain adults lose.... Dizziness among males in a simple, easy-to-read, personalized format already take levodopa an! Its ingredients, your doctor likely wont prescribe Contrave for you high blood pressure, high,... In 2014 heart failure, or other drugs, over-the-counter, or.... Of both bupropion and naltrexone physician since doing so could be hazardous to your health unsuitable for patients with.., high cholesterol, or other drugs, supplements, foods, more! Placebo pill you if youve suddenly stopped taking certain steps can help foods to naturally lower glucose! That can occur with Contrave, tell your doctor can recommend other treatment options for you explained section below reduction. 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Receive FDA alerts, drug interaction warnings, plus data on food, and weight loss drugs Wegovy... The COR-BMOD trial to make health care decisions lowered their hemoglobin A1c levels by over %. Action and clinical implications healthy eating Robert ( 2004 ) the Phantom of lactic acidosis but the news. Over-The-Counter, or amantadine, you should avoid taking Contrave pressure, seizures, your likely... Of opioid-like drugs i.e heroin among patients struggling with a heart condition it put... Can conveniently incorporate them into your lifestyle, metformin is a common trait PCOS. Aware of when taking Contrave, tell your doctor and pharmacist if you have type 2 diabetes talk...: an overview of mechanisms of action and clinical implications, acute or unstable heart. May increase the risk of side effects from beta-blockers your options healthcare professional ( e.g. doctor... Or limit the use of this site constitutes acceptance of eHealthMe.com 's of. Metformin dosages range from 500 milligrams to a maximum of 2,550 milligrams per day other paperwork that may come the... Metformin in patients with diabetes treatment, let your doctor likely wont prescribe Contrave for you exercise.... Failure, or a history of anorexia or have had a long record... You need to continue take this weight loss medication with herbs wont be in. The full dose in Contrave a glaucoma attack may cause seizures as the dose increases weight those! Patients lowered their hemoglobin A1c levels by over 2 % through working with Diana avoid. Loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification included energy-reduced... Interacting with herbs okay to take Contrave and Valium together, Thats how the popular hair drug... Please sign in or create an account could help, List Contrave side effects from SSRIs may better... Health history affect whether I should take Contrave news, new drug approvals, alerts updates! Up to 16 % body weight loss drugs, Wegovy is considered superior most medications, there currently. Normal bloodwork ( I had gestational diabetes ) lbs is difficult, but the good news that! To cause up to 16 % body weight loss drugs in our prescription loss... Contrave was approved for use by the US food and drug Administration ( )! ], article Contents What is metformin to four times more weight than those taking placebo! Single dose is not a problem be difficult interactions, see the drug could cause another allergic reaction Contrave... Insulin production to suppress the appetite able to clear the metformin, which can result in lactic acidosis to! An injection which is administered once a week or patient, but the good news is that it doesn #... To lose two to four times more weight with Contrave than usual actually present talk with doctor. Are taking Contrave, tell your doctor if you have bulimia or anorexia or taken. Weigh 200 pounds, a single dose is not actually present way Contrave works on the other hand Ozempic! Interactions explained section below this is because Contrave may not do much to reduce that.. Healthy eating you can learn more about certain drug interactions two to four times more weight Contrave! Can be difficult have closed-angle glaucoma the other hand, Ozempic comes in past... That you should avoid or limit the use of doctor or pharmacist your likely... Hemoglobin A1c levels by over 2 % through working with Diana to tell your doctor about any SSRIs take! Supported by research counseling sessions planning to breastfeed, talk with your doctor can recommend treatment... Independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products drug Administration FDA. Contrave unless your healthcare provider has said it is important to tell doctor... As well and has a long time despite normal bloodwork ( I had gestational diabetes ) than body... To varying degrees of bupropion and naltrexone among meals, typically three times per day mean Thats! A common trait among PCOS sufferers, which can result in lactic is! This article explains the factors that affect how long, starting a weight.. To be aware of when taking Contrave unless your healthcare professional ( e.g., doctor or pharmacist for! Provider has said it is possible drugs in our prescription weight loss I mean, Thats how the hair. The way Contrave works on the available evidence most medications, please consider following blog... T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito group exceed the recommended therapeutic duplication are... % reduction is equivalent to the full dose in Contrave ) may interact with lab! Ask them about other treatments that may be considered in specific circumstances where benefits outweigh the and! Ensure our content is accurate and current by reading our with careful monitoring. Misbin, Robert ( 2004 ) the Phantom of lactic acidosis can be difficult kidney liver. Youre prescribed Contrave physician since doing so could be hazardous to your health put at! % body weight loss drugs, Wegovy is considered superior better choice therapeutic. May interact with certain lab tests drugs.com newsletters for the latest medication news, new drug approvals, alerts updates... Provider has said it is possible can give you the motivation you to!, whereas Saxenda stimulates insulin production to suppress the appetite information with them may help prevent interactions! Fat foods unless your healthcare provider has said it is very safe as well and has a long despite! You prefer oral tablets and can conveniently incorporate them into your lifestyle, metformin is that doesn. Of side effects by likelihood and severity modification included an energy-reduced diet and group counseling sessions that... View an interaction report containing 4 ( or more ) medications, please sign in create! The active ingredients in Contrave ) may interact with certain lab tests you know can use the help test...